Received November 04, 2008
Accepted December 07, 2008

Objective: Endometriosis affects between 10 and 15% of women of reproductive age. These patients have a 20 greater chance of being infertile and 30-60% of these patients are actually infertile. In this study, the prevalence of the foliculle stimulating hormone (FSH) gene receptor polimorfism will be studied in infertile patients with endometriosis. This polimorfism, witch modify the signal receptor transduction, could probably be responsible for the poor ovarian response towards FSH stimulation. Material And Methods: Preliminary results of a case control study. The study group is infertile women with endometriosis. The control group is fertile patients without endometriosis. We will study the genotypic prevalence of the substitution of a aspargine (N) for a serine (S) in the 680 codon of exon 10 in both alleles of the FSH receptor gene synthesizer. Results: It was analyzed 49 patients, 31 in the study group and 18 in the control group. Both groups had nonstatistical differences regarding demographic characteristics. Among infertile patients with endometriosis, we found 5 homozygotic (S/S), 14 heterozygotic (N/S) and 12 genotipically normal (N/N). In the control group, we found 1 homozygotic (S/S), 9 heterozygotic (N/S) and 8 patients with normal genotype (N/N). There was no statistical difference between the groups (P>0,05). CONCLUSION: The FSH receptor polimorfism is related to abnormal ovarian response, and it has not been studied in women with endometriosis. This article is a worldwide pioneer study on this subject and rejects the hypothetical association between endometriosis and this genetic abnormality of the FSH receptor.