Ricardo L R Baruffi, Ana L Mauri, Cláudia G Petersen, Valéria Felipe, Anice M C Martins, João Cornicelli, Mario Cavagna, João Batista Oliveira, José G Franco Jr
JBRA Assist. Reprod. 2006; 10 (4):9-16
Received May 27, 2006
Accepted August 10, 2006
Abstract
The purpose of this investigation was to verify the efficacy of recombinant LH supplementation for controlled ovarian stimulation in GnRH-antagonist protocol for assisted reproductive technologies cycles. Search strategies included on-line surveys of databases from 1990 to 2006. In this review and meta-analysis, the observed advantages for the LH supplementation protocol were a higher serum estradiol levels on the day of hCG administration and a higher number of mature oocytes. However, there were no differences observed in the total amount of r-FSH administered, days of stimulation, number of oocyte retrieved, the clinical pregnancy rate per oocyte retrieval, the implantation rate and miscarriage rate. This result demonstrates that the association of r-LH with r-FSH may prevent any decrease in estradiol after antagonist administration and a significant higher number of mature oocytes was obtained. Nevertheless, additional randomized controlled trials are needed confirm these observations.
