J G Franco Jr, R L R Baruffi, A L Mauri, C G Petersen, V Felipe, J Cornicelli, M Cavagna, JBA Oliveira
JBRA Assist. Reprod. 2006; 10 (4):34-39
Received May 10, 2006
Accepted December 05, 2006
Abstract
The purpose of this investigation was to make a systematic review of the medical literature in order to compare the efficacy of GnRH antagonists and agonists for poor responders to ovarian stimulation. According to the data collected, the use of GnRH antagonist protocols showed better results in comparison to long protocols with a GnRH agonist regarding the following aspects: lower cycle cancellation rate due to poor ovarian response; higher number of oocytes retrieved; higher clinical pregnancy rate per initiated cycle.Nevertheless, these results were not observed when the flare-up protocols of GnRH agonists were used. Moreover the number of oocytes retrieved with GnRH agonist was significantly higher in relation to the GnRH antagonist.
