Patricia Diniz, Marcelo Aguiar Costa Lima, Cristina Werner, Elyzabeth Avvad Portari, Luiz Fernando Dale, Sérgio Simões
JBRA Assist. Reprod. 2005; 9 (2):31-34
Received June 28, 2005
Accepted July 14, 2005
Abstract
It has been suggested that there is an increased risk of congenital malformations in association with assisted reproduction techniques. We herein report a case of in utero diagnosis of caudal regression syndrome after intracytoplasmic sperm injection. The couple was referred for assisted reproduction due to advanced maternal age and pregnancy was achieved in the first cycle. Evaluation after 3 weeks showed single topic pregnancy. Ultra-sound scans performed at 19 and 21 weeks of gestation showed absence of sacral and lombar segments, suggesting caudal regression syndrome. Necropsy revealed absence of thoraxic and lumbosacral vertebrae, hypoplastic bladder and bilateral hydroureternephrosis.
