Received August 09, 2022
Accepted March 31, 2023

Objectives: The aim of this study was to evaluate whether the prolonged effect of GnRH-a on the luteal phase, in Assisted Reproduction cycles, might influence the pregnancy rates. Study design: This is a retrospective study of 367 patients who had been submitted to ovulation induction for lVF/lCSl procedures between January 1998 and December 2000, and used Depot GnRHa for pituitary suppression. Patients were stratified according to the period of action of the agonists in the luteal phase: first group ≤ 6 days; second group: 7 to 12 days (inclusive) and third group: > 12 days. The following variables were analyzed: ovarian response, age, infertility causes and pregnancy rates. Results: ln the first group (n = 53), the mean age was 33,8 (23-44) and the pregnancy rate was 45,2%. ln the second one (n = 118) the mean age was 33,5 (24-44) and the pregnancy rate was 38,9%. At last, in the third one (n = 196), the mean age was 33,8 (23-43) and the pregnancy rate was 47,4%. Conclusion: No significant association of prolonged effect of depot GnRH-a and pregnancy rates were found (p> 0,05). Discussion¦ Despite this conclusion, our findings suggest an increase in the pregnancy rates when GnRH-a effect lasts more than 12 days, which could represent an improvement in assisted reproduction procedures.