Received October 21, 1998
Accepted February 16, 1999

Empty follicle syndrome besides being un uncommon finding in vitro fertilization, has also been under questionning whether it really exists or not. This questionning seems to be due to the fact of most of the reported cases to be isolated ones and not repeated events in the same patient. ln the reported cases the "syndrome" has been related to the non biodisponibility of the HCG given prior to oocyte retrieval , with some of them being rescued by repeated injection of HCG in that very same cycle. The case we report here was the only one we had in 1 600 ln Vitro Fertilization treatment cycles. It reports two cycles, three months apart, in the same patient where no oocyte was aspirated in neither of them. This patient carne to develop a premature menopause at the age of 39, four years after the last in vitro cycle.