ARC Medeiros, E Borges Jr, A laconelli J r., T Aoki, J Hallak, CC Rocha, MEM Vieira
JBRA Assist. Reprod. 1999; 3 (2):6-10
Received April 22, 2023
Accepted May 16, 2023
Abstract
Introduction:The aim of this study was to compare cycles of ·ovulatory stimulation in which at least one blastomere was multinucleated (MNB ), originated from normalIy fertilized eggs (2PN), with those where just mononucleated embryos were observed.
Material and Methods:32cycles of ovulatory stimulation where at least one embryo presented with MNB (MNBG), were compared with 108 cycles where alI embryos had blastomeres with just one nucleus(control group CG). Ovulatory induction was performed using the long protocol with leuprolide acetate for lutheal phase blockage, folIowed by recombinant FSR
ResuIts:A total of 855 embryos were studied(266 from MNB G and 589 from CG). Forty-nine multinucleated embryos) were obtained. When compared both groups (MNBG and CG), the average number of follicles, oocytes, oocytes in MIl, 2PN and the average number of embryos, alI these parameters were significantly higher in the MNBG (18.5 vs 15.1(a); 12.8 vs 9.7(a); 9 vs 7.1(a); 7 vs 4.5(b); 83 vs 5.6(b); "Student t test"- a:P<0.05; b:P<00.1). Also, no difference was found in implantation (12% vs 11%) and pregnancy rates per transfer (33.3% vs 20.6%) and miscarriage rates(30% vs 28.5%) for MNBG and GC.
Conclusions: The presence of multinucleated blastomeres is associated with a higher response to the therapy with rFSR, reflected by the higher folIicular recruitment and higher number of oocytes. Although it is welI known that embryos with MNB present a smaller capacity of development and worst prognosis, its presence did not modified implantation rates, pregnancy and miscarriage rates in patients submitted to stimulation with rFSR and ICSI.
