Luciana Carvalho Delamuta, Georges Fassolas, João Antonio Dias Júnior, Luiz Fernando de Oliveira Henrique, Felipe Passos Martins Izzo, Carlos Roberto Izzo
JBRA Assist. Reprod. 2024; 28 (2):299-305
Received January 02, 2023
Accepted August 21, 2023
Abstract
Antimüllerian hormone (AMH) is a homodimeric glycoprotein secreted by granulosa cells from primary to large antral follicles and plays an important role in the regulation of early follicle growth. It is considered a reliable marker of ovarian reserve and a predictor of ovarian response to controlled stimulation. Polycystic ovary syndrome (PCOS) is endocrine condition that affects reproductive age women worldwide and is associated with high levels of AMH. It is known that PCOS patients may have worse maturation and fertilization rates compared to normo-ovulatory women. Some studies have demonstrated a positive correlation between AMH levels and qualitative aspects of assisted reproduction treatment, but it is not clear whether high levels of both serum and follicular fluid AMH in PCOS patients correlate with in vitro fertilization outcomes. The scoping review of the literature was made to address this specific question. We comprehensively search the databases Pubmed and Cochrane Library until January 2023. We found that higher AMH levels are associated with higher oocyte yield, but PCOS patients tend to have a smaller number of mature oocyte and impaired embryo quality and implantation rates. Pregnancy rates, however, are not affected by AMH levels or laboratorial outcomes. We also found that higher AMH levels are associated with worse features of PCOS.