Alexandre Barbosa de Albuquerque, Debora Antas Campello de Souza, Lara Chagas de Mendonça Brandão , Igor Glauber Braz rocha , Lara Bruno Araujo Nunes , Arthur Bruno de Araujo Medeiros , Guilherme Tavares da Silva Maia , Filipe Tenório Lira Neto
JBRA Assist. Reprod. - Advanced View
Received April 27, 2026
Accepted May 05, 2026
Abstract
Post-Orgasmic Illness Syndrome (POIS) is a rare condition characterized by flu-like symptoms after ejaculation, lasting several days and impairing quality of life. A 62-year-old man developed POIS after percutaneous epididymal sperm aspiration, with symptoms lasting seven days and worsening over six years. Multiple treatments offered minimal relief until combined therapy with tamsulosin, ebastine, escitalopram, and montelukast achieved complete resolution and restored sexual function. Immune hypersensitivity to seminal or epididymal antigens is a leading hypothesis. The success of α-blockers, antihistamines, and SSRIs highlights the interplay between immune, autonomic, and psychological mechanisms. POIS is a complex, underrecognized disorder. Multimodal therapy addressing both immune and neuropsychological pathways may yield optimal outcomes. Greater awareness and standardized diagnostic and treatment criteria are needed to improve management and research.
