Received June 12, 2026
Accepted June 18, 2026

Objective: To compare the effect of platelet-rich plasma (PRP) on pregnancy rates versus the placebo group in patients with normal endometrium undergoing advanced assisted reproduction treatments. Methods: Randomized, double-blind clinical trial that compared the use of PRP versus placebo (sterile saline solution) in patients undergoing endometrial preparation for frozen embryo transfer after in vitro fertilization. A total sample size of 52 patients was determined, and the patients were randomized into two groups (n = 26 per group). The groups were treated with either PRP or a placebo at the appropriate time. The impact on pregnancy rates and endometrial thickness was analyzed subsequently. Groups were compared using t-tests, U-tests, or chi-squared tests. A p-value <0.05 was considered statistically significant. Results: The study analyzed an intervention group (PRP) and a control group (placebo). The overall pregnancy rate during the study period (n = 52) was 38.4%, and the live birth rate was 33.3%. The pregnancy rate was 26.9% in the intervention group and 46.2% in the control group, with no significant difference between the groups (p = 0.15). Similarly, no differences were found in endometrial thickness and endometrial morphology between the groups analyzed (p > 0.05). Conclusion: There are no differences in favor of the PRP or control group in terms of achieving pregnancy, so the use of PRP in normal endometrium does not currently show advantages as an adjuvant to what is already used in women without other factors that alter endometrial receptivity.